As a protege of Lord Mortimer, Nell Bowen has fallen into being concerned with the human relations and treatment at St. Mary's of Bethlehem Asylum (a fictionalized version of Bethlem Royal Hospital) after an acquaintance of Mortimer's falls to his death when he tries to escape. She goes head to head with the apothecary general Master George Sims personally after discovering how the patients at the asylum are being treated. When she brings in Whig politican John Wilkes to help reform the asylum, Mortimer and Sims gets nervous and committs her to St. Mary's. But once Nell gets used to the horrible state of the patients, she prevails through nursing them physically and emotionally although Sims comes up with another idea to keep her mouth shut.
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